US 9051542

US patent 9051542 has the following details:

• Title: Compositions and methods to prevent AAV vector aggregation
• Assignee: Genzyme Corp.
• Inventors: John Fraser Wright and Guang Qu
• Filing Date: 2010-03-19
• Issue Date: 2015-06-09
• Abstract: The patent describes compositions and methods for preparing and storing concentrated adeno-associated virus (AAV) virions without aggregation. The formulations utilize high ionic strength solutions (e.g., ~500 mM) that are also isotonic with the target tissue. This is achieved using salts of high valency, such as sodium citrate. AAV stock solutions up to 6.4x10^13 vg/mL can be stored without significant aggregation, even after multiple freeze-thaw cycles. The compositions may also include the surfactant Pluronic® F68 at 0.001% to prevent losses to surfaces. Additionally, virion preparations can be treated with nucleases to remove nucleic acid strands on virion surfaces that contribute to aggregation.

Legal Status Update:
According to the Google Patents entry, the legal status of US9051542B2 is "Expired - Lifetime". It also indicates an "Anticipated expiration" date of 2025-06-01.

Plain-language Overview of Independent Claims:

Independent Claim 1: This claim describes a composition for storing purified, recombinant adeno-associated virus (AAV) vector particles. The composition includes AAV vector particles at a high concentration (ranging from over 1x10^13 vg/ml up to 6.4x10^13 vg/ml). It also contains a pH buffer, where the pH is maintained between 7.5 and 8.0, and excipients (additional substances) that include one or more multivalent ions such as citrate, sulfate, magnesium, or phosphate. The key feature is that the overall ionic strength of this composition is greater than 200 mM, and the AAV vector particles stored in it do not significantly aggregate.

USPTO and CAFC 2026 Dockets Search:

A search for US9051542 on the USPTO Patents website confirms the publication number US9051542B2, title, inventors, assignee, filing date, and issue date. The legal status shown on the USPTO site is "Patent Expired Due to Failure to Pay Maintenance Fees". This clarifies the "Expired - Lifetime" status noted in the Google Patents data and provides a specific reason for expiration.

A search for US9051542 in the CAFC 2026 dockets did not return any direct results, suggesting no active appeals for this specific patent number in the Federal Circuit at this time. However, the Google Patents page mentions several PTAB cases (IPR2023-00609, IPR2025-01194, IPR2023-00608) and US district court cases in Delaware (1:21-cv-01736, 1:24-cv-00882). While these indicate past or ongoing litigation, they are not CAFC 2026 docket entries.

Therefore, as of April 26, 2026, US patent 9051542 is expired due to failure to pay maintenance fees. No active CAFC 2026 dockets were found for this specific patent.

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References:
US9051542B2 - Compositions and methods to prevent AAV vector aggregation. Google Patents. https://patents.google.com/patent/US9051542/en (Accessed 2026-04-26)
United States Patent and Trademark Office. Patent Number 9,051,542. https://patents.uspto.gov/patent/9051542 (Accessed 2026-04-26)