US 12576084

US Patent 12576084, titled "Methods for treating testicular and ovarian adrenal rest tumors," was granted to Spruce Biosciences Inc. on March 17, 2026. The inventors are Alexis HOWERTON and Hal GERBER. The application (US19/043,303) was filed on January 31, 2025. While Spruce Biosciences Inc. is listed as the current assignee, a security interest was assigned to AVENUE CAPITAL MANAGEMENT II, L.P. on January 12, 2026.

Abstract:
The patent describes compounds and pharmaceutical compositions designed for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).

Plain-Language Overview of Independent Claims:

• Independent Claim 1: This claim covers a method for treating or preventing testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART). The method involves giving a patient in need a corticotropin-releasing factor type-1 (CRF1) antagonist or a pharmaceutically acceptable salt of such an antagonist.

• Independent Claim 7: This claim also describes a method for treating or preventing TART or OART. It specifies the administration of a compound with a particular chemical structure, referred to as Formula (I), or a pharmaceutically acceptable salt thereof. The claim further defines the possible chemical groups (R1, R2, R3, R4, Ra, and Rb) that can be part of this Formula (I) structure.

• Independent Claim 24: This claim outlines a method for treating or preventing TART or OART by administering a pharmaceutical composition. This composition includes a compound of the same structural Formula (I) as in Claim 7, along with a pharmaceutically acceptable excipient (an inactive substance that serves as a carrier for the active ingredient). The definitions for the R groups of Formula (I) are identical to those in Claim 7.

Litigation Search:
The Google Patents entry for US12576084B2 indicates that the "Family has litigation" and provides a link to Darts-ip for further details. However, a direct search of CAFC 2026 dockets did not yield specific case information for patent 12576084 at this time.