US 12569490

Here's a concise summary of US Patent 12,569,490:

Title: Methods for treating testicular and ovarian adrenal rest tumors

Assignee: Spruce Biosciences Inc. (Original Assignee) and AVENUE CAPITAL MANAGEMENT II, L.P. (Current Assignee, as of 2026-01-12, noting a security interest)

Inventors: Alexis HOWERTON, Hal GERBER

Filing Date: 2025-01-31 (Application number US19/043,264)

Issue Date: 2026-03-10

Abstract: Provided herein are compounds and pharmaceutical compositions for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).

Plain-language Overview of Independent Claims:

The patent US12569490B2 contains two independent claims (Claim 1 and Claim 10).

• Claim 1: This claim describes a method for treating or preventing testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART). The method involves administering a corticotropin-releasing factor type-1 (CRF1) antagonist, or a pharmaceutically acceptable salt of it, to a patient who needs such treatment.
• Claim 10: This claim describes a method for treating or preventing TART or OART by administering a pharmaceutical composition. This composition includes a compound with a specific structural Formula (I) (or a pharmaceutically acceptable salt thereof) and a pharmaceutically acceptable excipient. The claim further defines the possible chemical groups for R1, R2, R3, R4, Ra, and Rb within Formula (I).

CAFC 2026 Dockets:
As of April 26, 2026, a search of the provided CAFC 2026 dockets did not identify any listed litigation specifically referencing patent number US12569490.