Alexis Adian Smith

I'll research this attorney before drafting.

Alexis Adian Smith (practices as "Lexi Smith") — Jones Day, Los Angeles

Focus areas. Smith is a partner in Jones Day's Intellectual Property Practice in the Los Angeles office. Her publicly described work is weighted toward life sciences and chemistry-adjacent patent disputes — she has litigated method-of-treatment patents covering non-small cell lung cancer drugs, a gene therapy patent license arbitration, and trade secret/contract claims involving insulin technology — alongside mechanical and consumer-product matters such as vaporizing technology and strawberry plant patents, plus satellite television component claims. Jones Day's bio also lists trademark, copyright, false advertising, and unfair competition work. Her technical background is a B.S. in chemical engineering and four years as a practicing chemical engineer before law school, which tracks with the chemistry/pharma emphasis of the patent matters described.

Side preference. Her verified work runs both sides, so the single tracked appearance should not be read as a defense-only practice. The authoritative case list contains one matter, in which she is lead counsel for the defendant. But Jones Day's own experience listings and the Puma/Wyeth docket show her acting for patent owners and licensors as well: she led the damages presentation for Puma Biotechnology and Wyeth against AstraZeneca, secured a unanimous arbitration award for a gene therapy licensor, and helped an e-cigarette company obtain a favorable ITC initial determination recommending a general exclusion order. Nothing in the public record indicates NPE/PAE-side prosecution; her plaintiff-side work is for operating companies and licensors.

Notable matters. The most prominent verifiable result is Puma Biotechnology, Inc. v. AstraZeneca Pharmaceuticals LP, No. 1:21-cv-01338 (D. Del.), where a jury on May 17, 2024 returned a $107.5 million induced-infringement verdict on U.S. Patent Nos. 10,603,314 and 10,596,162 after a five-day trial and under three hours of deliberation. The outcome was later reversed in significant part: Judge Kennelly subsequently set aside the award and held the asserted claims invalid for lack of written description and enablement, while rejecting AstraZeneca's non-infringement and no-damages defenses. She has also litigated district court and Federal Circuit appeals concerning vaporizing technology; a Jones Day filing in Altria Client Services LLC v. R.J. Reynolds Vapor Co., No. 1:20-cv-00472 (M.D.N.C.) lists her as counsel. I could not confirm from public sources which specific matter corresponds to the single untitled defendant-side entry in the tracked case list.

PTAB/IPR. No IPR, PGR, or other PTAB appearances for this attorney appear in the sources reviewed; her described appellate experience is with the Federal Circuit rather than the Board. Treat that as an absence of evidence, not evidence of absence.

Bar and education. Admitted to the State Bar of California on December 9, 2010 (bar no. 274429, listed under the name Alexis Adian Houle Smith); J.D., UCLA School of Law, 2010; B.S., Chemical Engineering, University of Massachusetts Amherst, 2003. Her entire legal career appears to have been at Jones Day — first as associate, now partner; no prior firm or in-house affiliation was found. (Note: she is distinct from Alixandra E. Smith of the U.S. Attorney's Office for the Eastern District of New York, who appears in unrelated PLI materials.)