Hoffmann-La Roche Inc.

flowchart LR
    Nhoffmann_la_roche["Hoffmann-La Roche Inc."]
    Ncetus["Cetus Corporation"]
    Nroche_molecular_systems["Roche Molecular Systems, Inc."]
    Nf_hoffmann_la_roche["F. Hoffmann-La Roche AG"]
    Nhelsinn_healthcare["Helsinn Healthcare SA"]
    Nforschungszentrum_borstel_leibniz_lungenzentrum["Forschungszentrum Borstel, Leibniz Lung…"]
    Nhlr_technology["HLR Technology Corporation"]
    Nmullis_kary_b_erlich_henry_a_arnheim_norman_horn_glenn_t_sai["Mullis, Kary B.; Erlich, Henry A.; Arnh…"]
    Ndavid_h_gelfand_susanne_stoffel_frances_c_lawyer_randall_k_s["David H. Gelfand; Susanne Stoffel; Fran…"]
    Nkary_b_mullis_randall_k_saiki_henry_a_erlich_david_h_gelfand["Kary B. Mullis; Randall K. Saiki; Henry…"]
    Nroche_diagnostics["Roche Diagnostics GmbH"]
    Nwill_stephen_g["Will, Stephen G."]
    Nchristoph_funk_torsten_hoffmann_andreas_koblet["Christoph Funk; Torsten Hoffmann; Andre…"]
    Nlang_pierre["Lang, Pierre"]
    Nmichael_b_s_quirico_branca_guido_galley_thierry_godel_torste["Michael Bös; Quirico Branca; Guido Gall…"]
    Nkuentz_martin_roethlisberger_dieter["Kuentz, Martin; Roethlisberger, Dieter"]
    Nhans_hilpert_fabienne_hoffmann_emery_goesta_rimmler_mark_rog["Hans Hilpert; Fabienne Hoffmann-Emery;…"]
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can["Daniele Bonadeo; Riccardo Braglia; Robe…"]
    Ncannella_roberta_venturini_alessio["CANNELLA, ROBERTA; VENTURINI, ALESSIO"]
    Nluca_fadini_peter_manini_claudio_pietra_claudio_giuliano_ema["Luca Fadini; Peter Manini; Claudio Piet…"]
    Nluca_fadini_peter_manini_riccardo_braglia_roberta_cannella_c["Luca Fadini; Peter Manini; Riccardo Bra…"]
    Nfadini_luca_manini_peter_braglia_riccardo_cannella_roberta_g["FADINI, LUCA; MANINI, PETER; BRAGLIA, R…"]
    Nbonadeo_daniele_braglia_riccardo_cannella_roberta_cantoreggi["BONADEO, DANIELE; BRAGLIA, RICCARDO; CA…"]
    Nstella_valentino_j_cannella_roberta_fadini_luca_giuliano_cla["Stella, Valentino J; Cannella, Roberta;…"]
    Ncalderari_giorgio_bonadeo_daniel_braglia_enrico_cannella_rob["Calderari, Giorgio; Bonadeo, Daniel; Br…"]
    Nroche_palo_alto["Roche Palo Alto LLC"]
    Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel["Helsinn Advanced Synthesis SA; Helsinn…"]
    Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi["Helsinn Birex Pharmaceuticals, Ltd.; He…"]
    Ncalderari_giorgio_bonadeo_daniele_cannella_roberta_panuccio_["Calderari, Giorgio; Bonadeo, Daniele; C…"]
    Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_["Helsinn Advanced Synthesis SA; Helsinn…"]
    Ngiorgio_calderari_daniele_bonadeo_roberta_cannella_enrico_br["Giorgio Calderari; Daniele Bonadeo; Rob…"]
    Ndaniele_bonadeo_enrico_braglia_riccardo_braglia_giorgio_cald["Daniele Bonadeo; Enrico Braglia; Riccar…"]
    Nmacciocchi_alberto_bonadeo_daniele_calderari_giorgio_cannell["Macciocchi, Alberto; Bonadeo, Daniele;…"]
    Nbonadeo_daniel_braglia_enrico_braglia_riccardo_calderari_gio["BONADEO, DANIEL; BRAGLIA, ENRICO; BRAGL…"]
    Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_["HELSINN ADVANCED SYNTHESIS SA; HELSINN…"]
    Ngiulio_macciocchi_simone_macciocchi_daniele_bonadeo_giorgio_["Giulio Macciocchi; Simone Macciocchi; D…"]
    Nhas_helsinn_advanced_synthesis_helsinn_therapeutics_u_s_hels["HAS Helsinn Advanced Synthesis SA; Hels…"]
    Nalberto_macciocchi_daniele_bonadeo_giorgio_calderari_roberta["Alberto Macciocchi; Daniele Bonadeo; Gi…"]
    Nsyntex_u["Syntex (U.S.A.) Inc."]
    Ncetus ==>|"⚖️ 1991 · Assignment · 4683195"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 4683195"| Nroche_molecular_systems
    Ncetus ==>|"⚖️ Assignment · 4889818"| Nhoffmann_la_roche
    Nhoffmann_la_roche ==>|"⚖️ Assignment · 4889818"| Nroche_molecular_systems
    Ncetus -->|"1992 · Assignment · 5057410"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 5057410"| Nroche_molecular_systems
    Ncetus -->|"1991 · Assignment · 4965188"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 4965188"| Nroche_molecular_systems
    Ncetus -->|"1992 · Assignment · 4800159"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 4800159"| Nroche_molecular_systems
    Nf_hoffmann_la_roche -->|"2006 · Assignment · 7211579"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"2014 · Assignment · 7211579"| Nhelsinn_healthcare
    Nf_hoffmann_la_roche -->|"2018 · Assignment · 10585097"| Nhoffmann_la_roche
    Nforschungszentrum_borstel_leibniz_lungenzentrum -->|"2022 · Assignment · 10585097"| Nhoffmann_la_roche
    Nf_hoffmann_la_roche -->|"2000 · Assignment · 6297375"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1999 · Assignment · 4280957"| Nhlr_technology
    Nf_hoffmann_la_roche -->|"2001 · Assignment · 6719996"| Nhoffmann_la_roche
    Nf_hoffmann_la_roche -->|"2000 · Assignment · 6303790"| Nhoffmann_la_roche
    Nmullis_kary_b_erlich_henry_a_arnheim_norman_horn_glenn_t_sai -->|"1986 · Assignment · 4683195"| Ncetus
    Ndavid_h_gelfand_susanne_stoffel_frances_c_lawyer_randall_k_s -->|"1987 · Assignment · 4889818"| Ncetus
    Nkary_b_mullis_randall_k_saiki_henry_a_erlich_david_h_gelfand -->|"1987 · Assignment · 4965188"| Ncetus
    Nroche_diagnostics -->|"2022 · Assignment · 11353382"| Nroche_molecular_systems
    Nwill_stephen_g -->|"2022 · Assignment · 11353382"| Nroche_molecular_systems
    Nchristoph_funk_torsten_hoffmann_andreas_koblet -->|"2006 · Assignment · 7211579"| Nf_hoffmann_la_roche
    Nlang_pierre -->|"2018 · Assignment · 10585097"| Nf_hoffmann_la_roche
    Nroche_diagnostics -->|"2018 · Assignment · 10585097"| Nf_hoffmann_la_roche
    Nmichael_b_s_quirico_branca_guido_galley_thierry_godel_torste -->|"2000 · Assignment · 6297375"| Nf_hoffmann_la_roche
    Nkuentz_martin_roethlisberger_dieter -->|"2001 · Assignment · 6719996"| Nf_hoffmann_la_roche
    Nhans_hilpert_fabienne_hoffmann_emery_goesta_rimmler_mark_rog -->|"2000 · Assignment · 6303790"| Nf_hoffmann_la_roche
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can ==>|"⚖️ 2018 · Assignment · 10828297"| Nhelsinn_healthcare
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can -->|"2016 · Assignment · 9943515"| Nhelsinn_healthcare
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can -->|"2011 · Assignment · 8623826"| Nhelsinn_healthcare
    Ncannella_roberta_venturini_alessio ==>|"⚖️ 2017 · Assignment · 10624911"| Nhelsinn_healthcare
    Nluca_fadini_peter_manini_claudio_pietra_claudio_giuliano_ema ==>|"⚖️ 2018 · Assignment · 10208073"| Nhelsinn_healthcare
    Nluca_fadini_peter_manini_riccardo_braglia_roberta_cannella_c ==>|"⚖️ 2012 · Assignment · 8426450"| Nhelsinn_healthcare
    Nfadini_luca_manini_peter_braglia_riccardo_cannella_roberta_g ==>|"⚖️ 2018 · Assignment · 8895586"| Nhelsinn_healthcare
    Nbonadeo_daniele_braglia_riccardo_cannella_roberta_cantoreggi -->|"2015 · Assignment · 9271975"| Nhelsinn_healthcare
    Nstella_valentino_j_cannella_roberta_fadini_luca_giuliano_cla ==>|"⚖️ 2017 · Assignment · 9908907"| Nhelsinn_healthcare
    Ncalderari_giorgio_bonadeo_daniel_braglia_enrico_cannella_rob -->|"2006 · Assignment · 7960424"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 7960424"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Assignment · 7960424"| Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel
    Nhelsinn_healthcare -->|"2018 · Correction · 7960424"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ncalderari_giorgio_bonadeo_daniele_cannella_roberta_panuccio_ -->|"2013 · Assignment · 8598219"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 8598219"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 8598219"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Corrective Assignment · 8598219"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ngiorgio_calderari_daniele_bonadeo_roberta_cannella_enrico_br -->|"2006 · Assignment · 7947725"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 7947725"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Assignment · 7947725"| Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel
    Ndaniele_bonadeo_enrico_braglia_riccardo_braglia_giorgio_cald -->|"2006 · Assignment · 7947724"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 7947724"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 7947724"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Correction · 7947724"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nroche_palo_alto -->|"2016 · Assignment · 9066980"| Nhelsinn_healthcare
    Nmacciocchi_alberto_bonadeo_daniele_calderari_giorgio_cannell -->|"2018 · Assignment · 9066980"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 9066980"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Correction · 9066980"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ncannella_roberta_venturini_alessio -->|"2020 · Assignment · 11529362"| Nhelsinn_healthcare
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can -->|"2015 · Assignment · 8951969"| Nhelsinn_healthcare
    Nbonadeo_daniel_braglia_enrico_braglia_riccardo_calderari_gio ==>|"⚖️ Assignment · 8518981"| Nhelsinn_healthcare
    Nroche_palo_alto ==>|"⚖️ Assignment · 8518981"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"Patent Co-Ownership Agreement · 8518981"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"Corrective Assignment · 8518981"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ngiulio_macciocchi_simone_macciocchi_daniele_bonadeo_giorgio_ ==>|"⚖️ 2015 · Assignment · 9125905"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 9125905"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Assignment · 9125905"| Nhas_helsinn_advanced_synthesis_helsinn_therapeutics_u_s_hels
    Nhelsinn_healthcare -->|"2018 · Correction · 9125905"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nroche_palo_alto -->|"2016 · Assignment · 8729094"| Nhelsinn_healthcare
    Nalberto_macciocchi_daniele_bonadeo_giorgio_calderari_roberta -->|"2018 · Assignment · 8729094"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 8729094"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Correction · 8729094"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nsyntex_u -->|"1999 · Assignment · 5510486"| Nhelsinn_healthcare
    Nbonadeo_daniele_braglia_riccardo_cannella_roberta_cantoreggi ==>|"⚖️ 2015 · Assignment · 9186357"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 9173942"| Nhelsinn_healthcare
    Nalberto_macciocchi_daniele_bonadeo_giorgio_calderari_roberta -->|"2018 · Assignment · 9173942"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 9173942"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Corrective Assignment · 9173942"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nstella_valentino_j_cannella_roberta_fadini_luca_giuliano_cla ==>|"⚖️ 2013 · Assignment · 9403772"| Nhelsinn_healthcare
    classDef focal fill:#fef3c7,stroke:#92400e,stroke-width:3px,color:#1c1917
    classDef npe fill:#fee2e2,stroke:#be123c,stroke-width:2px,color:#1c1917
    classDef shell fill:#fed7aa,stroke:#9a3412,stroke-width:2px,color:#1c1917
    classDef defensive fill:#dcfce7,stroke:#15803d,stroke-width:2px,color:#1c1917
    classDef operating fill:#e0f2fe,stroke:#075985,stroke-width:1px,color:#1c1917
    class Nhoffmann_la_roche focal
    class Ncetus operating
    class Nroche_molecular_systems operating
    class Nf_hoffmann_la_roche operating
    class Nhelsinn_healthcare operating
    class Nroche_diagnostics operating
    class Nroche_palo_alto operating
    class Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel operating
    class Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi operating
    class Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_ operating
    class Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_ operating
    class Nhas_helsinn_advanced_synthesis_helsinn_therapeutics_u_s_hels operating
    class Nsyntex_u operating