Helsinn Healthcare SA

flowchart LR
    Nhelsinn_healthcare["Helsinn Healthcare SA"]
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can["Daniele Bonadeo; Riccardo Braglia; Robe…"]
    Ncannella_roberta_venturini_alessio["CANNELLA, ROBERTA; VENTURINI, ALESSIO"]
    Nluca_fadini_peter_manini_claudio_pietra_claudio_giuliano_ema["Luca Fadini; Peter Manini; Claudio Piet…"]
    Nluca_fadini_peter_manini_riccardo_braglia_roberta_cannella_c["Luca Fadini; Peter Manini; Riccardo Bra…"]
    Nfadini_luca_manini_peter_braglia_riccardo_cannella_roberta_g["FADINI, LUCA; MANINI, PETER; BRAGLIA, R…"]
    Nbonadeo_daniele_braglia_riccardo_cannella_roberta_cantoreggi["BONADEO, DANIELE; BRAGLIA, RICCARDO; CA…"]
    Nstella_valentino_j_cannella_roberta_fadini_luca_giuliano_cla["Stella, Valentino J; Cannella, Roberta;…"]
    Ncalderari_giorgio_bonadeo_daniel_braglia_enrico_cannella_rob["Calderari, Giorgio; Bonadeo, Daniel; Br…"]
    Nroche_palo_alto["Roche Palo Alto LLC"]
    Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel["Helsinn Advanced Synthesis SA; Helsinn…"]
    Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi["Helsinn Birex Pharmaceuticals, Ltd.; He…"]
    Ncalderari_giorgio_bonadeo_daniele_cannella_roberta_panuccio_["Calderari, Giorgio; Bonadeo, Daniele; C…"]
    Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_["Helsinn Advanced Synthesis SA; Helsinn…"]
    Ngiorgio_calderari_daniele_bonadeo_roberta_cannella_enrico_br["Giorgio Calderari; Daniele Bonadeo; Rob…"]
    Ndaniele_bonadeo_enrico_braglia_riccardo_braglia_giorgio_cald["Daniele Bonadeo; Enrico Braglia; Riccar…"]
    Nmacciocchi_alberto_bonadeo_daniele_calderari_giorgio_cannell["Macciocchi, Alberto; Bonadeo, Daniele;…"]
    Nhoffmann_la_roche["Hoffmann-La Roche Inc."]
    Nbonadeo_daniel_braglia_enrico_braglia_riccardo_calderari_gio["BONADEO, DANIEL; BRAGLIA, ENRICO; BRAGL…"]
    Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_["HELSINN ADVANCED SYNTHESIS SA; HELSINN…"]
    Ngiulio_macciocchi_simone_macciocchi_daniele_bonadeo_giorgio_["Giulio Macciocchi; Simone Macciocchi; D…"]
    Nhas_helsinn_advanced_synthesis_helsinn_therapeutics_u_s_hels["HAS Helsinn Advanced Synthesis SA; Hels…"]
    Nalberto_macciocchi_daniele_bonadeo_giorgio_calderari_roberta["Alberto Macciocchi; Daniele Bonadeo; Gi…"]
    Nsyntex_u["Syntex (U.S.A.) Inc."]
    Nmiksztal_andrew_malefyt_thomas_lee_kathleen_m["Miksztal, Andrew; Malefyt, Thomas; Lee,…"]
    Nmalefyt_thomas_miksztal_andrew_lee_kathleen_m["Malefyt, Thomas; Miksztal, Andrew; Lee,…"]
    Nandrew_miksztal_thomas_malefyt_kathleen_m_lee["Andrew Miksztal; Thomas Malefyt; Kathle…"]
    Nkathleen_m_lee_andrew_miksztal_thomas_malefyt["Kathleen M. Lee; Andrew Miksztal; Thoma…"]
    Nlee_kathleen_m_miksztal_andrew_malefyt_thomas["LEE, KATHLEEN M.; MIKSZTAL, ANDREW; MAL…"]
    Nthomas_malefyt_andrew_miksztal_kathleen_m_lee["Thomas Malefyt; Andrew Miksztal; Kathle…"]
    Ncetus["Cetus Corporation"]
    Nroche_molecular_systems["Roche Molecular Systems, Inc."]
    Nf_hoffmann_la_roche["F. Hoffmann-La Roche AG"]
    Nforschungszentrum_borstel_leibniz_lungenzentrum["Forschungszentrum Borstel, Leibniz Lung…"]
    Nhlr_technology["HLR Technology Corporation"]
    Nrobinson_james_iii_rohloff_john_christian_kowalczyk_bruce_an["Robinson, James III; Rohloff, John Chri…"]
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can ==>|"⚖️ 2018 · Assignment · 10828297"| Nhelsinn_healthcare
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can -->|"2016 · Assignment · 9943515"| Nhelsinn_healthcare
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can -->|"2011 · Assignment · 8623826"| Nhelsinn_healthcare
    Ncannella_roberta_venturini_alessio ==>|"⚖️ 2017 · Assignment · 10624911"| Nhelsinn_healthcare
    Nluca_fadini_peter_manini_claudio_pietra_claudio_giuliano_ema ==>|"⚖️ 2018 · Assignment · 10208073"| Nhelsinn_healthcare
    Nluca_fadini_peter_manini_riccardo_braglia_roberta_cannella_c ==>|"⚖️ 2012 · Assignment · 8426450"| Nhelsinn_healthcare
    Nfadini_luca_manini_peter_braglia_riccardo_cannella_roberta_g ==>|"⚖️ 2018 · Assignment · 8895586"| Nhelsinn_healthcare
    Nbonadeo_daniele_braglia_riccardo_cannella_roberta_cantoreggi -->|"2015 · Assignment · 9271975"| Nhelsinn_healthcare
    Nstella_valentino_j_cannella_roberta_fadini_luca_giuliano_cla ==>|"⚖️ 2017 · Assignment · 9908907"| Nhelsinn_healthcare
    Ncalderari_giorgio_bonadeo_daniel_braglia_enrico_cannella_rob -->|"2006 · Assignment · 7960424"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 7960424"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Assignment · 7960424"| Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel
    Nhelsinn_healthcare -->|"2018 · Correction · 7960424"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ncalderari_giorgio_bonadeo_daniele_cannella_roberta_panuccio_ -->|"2013 · Assignment · 8598219"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 8598219"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 8598219"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Corrective Assignment · 8598219"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ngiorgio_calderari_daniele_bonadeo_roberta_cannella_enrico_br -->|"2006 · Assignment · 7947725"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 7947725"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Assignment · 7947725"| Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel
    Ndaniele_bonadeo_enrico_braglia_riccardo_braglia_giorgio_cald -->|"2006 · Assignment · 7947724"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 7947724"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 7947724"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Correction · 7947724"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nroche_palo_alto -->|"2016 · Assignment · 9066980"| Nhelsinn_healthcare
    Nmacciocchi_alberto_bonadeo_daniele_calderari_giorgio_cannell -->|"2018 · Assignment · 9066980"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 9066980"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Correction · 9066980"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ncannella_roberta_venturini_alessio -->|"2020 · Assignment · 11529362"| Nhelsinn_healthcare
    Nhoffmann_la_roche -->|"2014 · Assignment · 7211579"| Nhelsinn_healthcare
    Ndaniele_bonadeo_riccardo_braglia_roberta_cannella_sergio_can -->|"2015 · Assignment · 8951969"| Nhelsinn_healthcare
    Nbonadeo_daniel_braglia_enrico_braglia_riccardo_calderari_gio ==>|"⚖️ Assignment · 8518981"| Nhelsinn_healthcare
    Nroche_palo_alto ==>|"⚖️ Assignment · 8518981"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"Patent Co-Ownership Agreement · 8518981"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"Corrective Assignment · 8518981"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Ngiulio_macciocchi_simone_macciocchi_daniele_bonadeo_giorgio_ ==>|"⚖️ 2015 · Assignment · 9125905"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 9125905"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Assignment · 9125905"| Nhas_helsinn_advanced_synthesis_helsinn_therapeutics_u_s_hels
    Nhelsinn_healthcare -->|"2018 · Correction · 9125905"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nroche_palo_alto -->|"2016 · Assignment · 8729094"| Nhelsinn_healthcare
    Nalberto_macciocchi_daniele_bonadeo_giorgio_calderari_roberta -->|"2018 · Assignment · 8729094"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 8729094"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Correction · 8729094"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nsyntex_u -->|"1999 · Assignment · 5510486"| Nhelsinn_healthcare
    Nbonadeo_daniele_braglia_riccardo_cannella_roberta_cantoreggi ==>|"⚖️ 2015 · Assignment · 9186357"| Nhelsinn_healthcare
    Nroche_palo_alto -->|"2016 · Assignment · 9173942"| Nhelsinn_healthcare
    Nalberto_macciocchi_daniele_bonadeo_giorgio_calderari_roberta -->|"2018 · Assignment · 9173942"| Nhelsinn_healthcare
    Nhelsinn_healthcare -->|"2018 · Patent Co-Ownership Agreement · 9173942"| Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_
    Nhelsinn_healthcare -->|"2018 · Corrective Assignment · 9173942"| Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi
    Nstella_valentino_j_cannella_roberta_fadini_luca_giuliano_cla ==>|"⚖️ 2013 · Assignment · 9403772"| Nhelsinn_healthcare
    Nmiksztal_andrew_malefyt_thomas_lee_kathleen_m ==>|"⚖️ 2010 · Assignment · 7960424"| Nroche_palo_alto
    Nmalefyt_thomas_miksztal_andrew_lee_kathleen_m -->|"2013 · Assignment · 8598219"| Nroche_palo_alto
    Nandrew_miksztal_thomas_malefyt_kathleen_m_lee ==>|"⚖️ 2010 · Assignment · 7947725"| Nroche_palo_alto
    Nkathleen_m_lee_andrew_miksztal_thomas_malefyt ==>|"⚖️ 2010 · Assignment · 7947724"| Nroche_palo_alto
    Nmalefyt_thomas_miksztal_andrew_lee_kathleen_m -->|"2018 · Assignment · 9066980"| Nroche_palo_alto
    Nlee_kathleen_m_miksztal_andrew_malefyt_thomas ==>|"⚖️ Assignment · 8518981"| Nroche_palo_alto
    Nandrew_miksztal_thomas_malefyt_kathleen_m_lee -->|"2015 · Assignment · 9125905"| Nroche_palo_alto
    Nthomas_malefyt_andrew_miksztal_kathleen_m_lee -->|"2018 · Assignment · 8729094"| Nroche_palo_alto
    Nthomas_malefyt_andrew_miksztal_kathleen_m_lee -->|"2018 · Assignment · 9173942"| Nroche_palo_alto
    Ncetus ==>|"⚖️ 1991 · Assignment · 4683195"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 4683195"| Nroche_molecular_systems
    Ncetus ==>|"⚖️ Assignment · 4889818"| Nhoffmann_la_roche
    Nhoffmann_la_roche ==>|"⚖️ Assignment · 4889818"| Nroche_molecular_systems
    Ncetus -->|"1992 · Assignment · 5057410"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 5057410"| Nroche_molecular_systems
    Ncetus -->|"1991 · Assignment · 4965188"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 4965188"| Nroche_molecular_systems
    Ncetus -->|"1992 · Assignment · 4800159"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1997 · Assignment · 4800159"| Nroche_molecular_systems
    Nf_hoffmann_la_roche -->|"2006 · Assignment · 7211579"| Nhoffmann_la_roche
    Nf_hoffmann_la_roche -->|"2018 · Assignment · 10585097"| Nhoffmann_la_roche
    Nforschungszentrum_borstel_leibniz_lungenzentrum -->|"2022 · Assignment · 10585097"| Nhoffmann_la_roche
    Nf_hoffmann_la_roche -->|"2000 · Assignment · 6297375"| Nhoffmann_la_roche
    Nhoffmann_la_roche -->|"1999 · Assignment · 4280957"| Nhlr_technology
    Nf_hoffmann_la_roche -->|"2001 · Assignment · 6719996"| Nhoffmann_la_roche
    Nf_hoffmann_la_roche -->|"2000 · Assignment · 6303790"| Nhoffmann_la_roche
    Nrobinson_james_iii_rohloff_john_christian_kowalczyk_bruce_an -->|"1994 · Assignment · 5510486"| Nsyntex_u
    classDef focal fill:#fef3c7,stroke:#92400e,stroke-width:3px,color:#1c1917
    classDef npe fill:#fee2e2,stroke:#be123c,stroke-width:2px,color:#1c1917
    classDef shell fill:#fed7aa,stroke:#9a3412,stroke-width:2px,color:#1c1917
    classDef defensive fill:#dcfce7,stroke:#15803d,stroke-width:2px,color:#1c1917
    classDef operating fill:#e0f2fe,stroke:#075985,stroke-width:1px,color:#1c1917
    class Nhelsinn_healthcare focal
    class Nroche_palo_alto operating
    class Nhelsinn_advanced_synthesis_helsinn_birex_pharmaceuticals_hel operating
    class Nhelsinn_birex_pharmaceuticals_helsinn_therapeutics_u_s_helsi operating
    class Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_ operating
    class Nhoffmann_la_roche operating
    class Nhelsinn_advanced_synthesis_helsinn_therapeutics_u_s_helsinn_ operating
    class Nhas_helsinn_advanced_synthesis_helsinn_therapeutics_u_s_hels operating
    class Nsyntex_u operating
    class Ncetus operating
    class Nroche_molecular_systems operating
    class Nf_hoffmann_la_roche operating