Prior art

U.S. Patent 10,865,400, titled "PH20 polypeptide variants, formulations and uses thereof," was issued on December 15, 2020, from an application filed on August 2, 2016. The patent describes modified PH20 hyaluronidase polypeptides that exhibit increased stability and/or increased activity, as well as compositions, formulations, and uses thereof.

To identify the most relevant prior art, we need to examine the citations listed in the patent. Based on the provided information, I cannot directly access a comprehensive list of all cited prior art within US10865400B2 and their specific claims. The Google Patents link provides a "Citations" section but only lists two "APP" (application) type citations: US-3536809-A and US-3598123-A. It does not provide detailed descriptions or direct mapping to claims. To perform a thorough analysis of all patent citations and their potential anticipation of claims under 35 U.S.C. § 102, I would need access to the full patent document from the USPTO website, including its "References Cited" section and the text of each cited patent.

However, based on the abstract and description of US10865400B2, the focus is on modified PH20 hyaluronidase polypeptides with increased stability and/or activity, particularly in the presence of denaturing conditions like phenolic preservatives or elevated temperatures, or under low salt conditions. Therefore, any prior art disclosing PH20 hyaluronidase variants with improved stability or activity under similar conditions would be highly relevant.

One directly related patent family member mentioned in the search results is US9284543B2, titled "Neutral active soluble truncated PH20 polypeptides and uses thereof". This patent (US9284543B2) shares the same priority date as US10865400B2, indicating a close relationship. It focuses on soluble truncated PH20 polypeptides. While it is a family member, it also serves as relevant prior art in the broader context of PH20 modifications and uses.

Without direct access to the "References Cited" section of US10865400B2 and the full text of each cited patent within the USPTO database, a comprehensive analysis of claim anticipation is not possible.

To proceed with a full prior art analysis, the following steps would be necessary:

1. Obtain the full "References Cited" list for US10865400B2 from the USPTO Patent Public Search tool. This list would include all U.S. patents, foreign patents, and non-patent literature cited by the examiner and applicant.
2. Retrieve the full text of each cited patent.
3. Analyze each cited reference to:
   • Extract a detailed description of its disclosed invention.
   • Identify specific elements that correspond to the claims of US10865400B2.
   • Determine if any single prior art reference (or combination thereof, for obviousness under 35 U.S.C. § 103) discloses all elements of a given claim of US10865400B2, thereby potentially anticipating it under 35 U.S.C. § 102.